Rainero Lab

Rainero Lab The Rainero's lab at the University of Sheffield focuses on understanding the role of extracellular

The Rainero's lab at the University of Sheffield focuses on understanding the role of extracellular matrix uptake in cancer cell growth and invasion

Fantastic lab walk in the Peak District!
02/07/2025

Fantastic lab walk in the Peak District!

Welcome to the lab Fatmagul!! Joining the lab summer walk is a great way to start!
02/07/2025

Welcome to the lab Fatmagul!! Joining the lab summer walk is a great way to start!

New addition to our lab's PhD Wall of Fame - Bian 🇸🇾
12/06/2025

New addition to our lab's PhD Wall of Fame - Bian 🇸🇾

Congratulations to Bian on passing her PhD viva!!! Well deserved!
05/06/2025

Congratulations to Bian on passing her PhD viva!!! Well deserved!

Our recent paper is now highlighted in  :
18/12/2024

Our recent paper is now highlighted in :

Our latest paper is out!!!Novel kinase regulators of extracellular matrix internalisation identified by high-content scr...
17/12/2024

Our latest paper is out!!!
Novel kinase regulators of extracellular matrix internalisation identified by high-content screening modulate invasive carcinoma cell migration

This study identifies novel kinase regulators of extracellular matrix (ECM) internalization through a high-content screen, characterizing the α2β1 integrin/p38 signaling axis as required for the internalization integrin-bound ECM, which modulates cell migration and invasion in breast, ovarian and ...

Yay!!! Bian won a best poster prize 🏆 at the NECB2024!!!
20/09/2024

Yay!!! Bian won a best poster prize 🏆 at the NECB2024!!!

Great presentation by Rachele at the 3rd year PGR symposium today + a fantastic 'express my PhD' artwork!!
12/09/2024

Great presentation by Rachele at the 3rd year PGR symposium today + a fantastic 'express my PhD' artwork!!

New preprint from our lab by Sherry & Rachele: "The protease ADAMTS5 controls ovarian cancer cell invasion, downstream o...
12/07/2024

New preprint from our lab by Sherry & Rachele: "The protease ADAMTS5 controls ovarian cancer cell invasion, downstream of Rab25"

Ovarian cancer is the 3rd most common gynaecological malignancy worldwide, with a 5-year survival rate of less than 30% in the presence of metastasis. Metastatic progression is characterised by extensive remodelling of the extracellular matrix, primarily mediated by secreted matrix metalloproteinase...

Huge congratulations to Dr Sherry on brilliantly passing her PhD viva!!!
12/07/2024

Huge congratulations to Dr Sherry on brilliantly passing her PhD viva!!!

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