Laboratory of Recombination and DNA Repair

Laboratory of Recombination and DNA Repair Research laboratory DNA double-strand breaks (DSB) are among the most lethal forms of DNA damage.

DSBs are induced by a large number of endogenous and exogenous agents, as genotoxic chemicals and ionizing radiation, or due to replication of damaged DNA as well as collapse of a replication fork. DSB can either be properly repaired, restoring genomic integrity, or miss-repaired resulting in cell death, genomic instability, and cancer. Our group focuses on mechanisms of DSB repair using multi-disciplinary approach (biochemical, structural, computational, genetic, and single-molecule).

Happy Holidays! 🎄☃️🍾💕☮️We really enjoyed visiting St. James church!
09/12/2025

Happy Holidays! 🎄☃️🍾💕☮️
We really enjoyed visiting St. James church!

We are so proud to share with you the great news! Our SOČ student, Anna Černá, won the first prize at the European Union...
08/10/2025

We are so proud to share with you the great news! Our SOČ student, Anna Černá, won the first prize at the European Union Contest for Young Scientists with her Biology project!! 🤩
CONGRATULATIONS!! 👏👏👏🥳
https://www.eucys2025.eu/en/participants/eucys-2025-winners/
Photo: Jānis Porietis
Splendid Palace. Apbalvošana.19.09.2025.

Happy to see our newest collaborative manuscript published in Mol Cell! We hope this work will substantiate the role of ...
09/06/2025

Happy to see our newest collaborative manuscript published in Mol Cell! We hope this work will substantiate the role of biomolecular condensates in the regulation of DNA repair and chromatin organization.

Merigliano et al. identified a non-canonical, “off-pore” role for nucleoporins in genome stability and in the spatial regulation of homologous recombination in multicellular eukaryotes. Nup98 condensates form at DNA breaks within pericentromeric heterochromatin to prevent aberrant recombination ...

We are grateful to have received a 3-year research grant from the Czech Science Foundation, in collaboration with Karel ...
02/12/2024

We are grateful to have received a 3-year research grant from the Czech Science Foundation, in collaboration with Karel Kubíček, to study the structure and biological role of the RAD51 protein. 🤩
https://www.facebook.com/GrantovaAgenturaCR/

Our PI Lumir Krejci is among the newly elected EMBO members. Congratulations!! 😃
15/11/2024

Our PI Lumir Krejci is among the newly elected EMBO members. Congratulations!! 😃

Hana Polášek-Sedláčková, former member of our lab, presents her work as an EMBO Installation grantee in Heidelberg at th...
04/11/2024

Hana Polášek-Sedláčková, former member of our lab, presents her work as an EMBO Installation grantee in Heidelberg at the Meeting of the EMBO Communities.

We are very happy to share the fantastic news! 😃Anna Černá, a high school student in our lab, has won the Czech state co...
15/10/2024

We are very happy to share the fantastic news! 😃Anna Černá, a high school student in our lab, has won the Czech state competition (SOČ) in Molecular Biology! 🎉Let’s wish her luck in her future endeavours! 🍀
https://www.soc.cz/

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Kamenice 5 A7
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62500

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