CellNetworks

CellNetworks Cluster of Excellence Cellular Networks at Heidelberg University Frontier Science requires frontier technology.

The cluster enhances Heidelberg’s outstanding focus on life-science with expertise from physical chemistry, biophysics, material science, engineering and advanced computation to create a powerful interdisciplinary platform well suited to sophisticated challenges. CellNetworks applies this integrative approach to achieve new and profound insight into biological networks drawn from the four focus ar

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- Biogenesis, Interactions and Regulation of Protein Machines,
- Dynamics of Cell Architecture,
- Information Processing in Complex Multi-Cellular Networks,
- Alteration of Networks by Infectious Pathogens. The sophisticated challenges the cluster faces demand powerful and often costly technology, normally exceeding single groups’ capabilities. Its unique structure allows CellNetworks to provide state-of-the-art technology to all cluster members, including

· deep sequencing
· electron and cryoelectron microscopy
· light microscopy (Nikon Imaging Center)
· RNAi screening
· protein crystallisation
· mass spectrometry
· single molecule spectroscopy
· high-end computation, simulation and modeling

Strongly emphasising method development, CellNetworks continuously expands available technologies and techniques. Cluster membership thus provides research groups with powerful technological resources otherwise not at their disposal.

"Cellular Behavior in Natural and Synthetic Environments," a virtual mini-symposium, organised by COS Heidelberg , Clust...
07/06/2020

"Cellular Behavior in Natural and Synthetic Environments," a virtual mini-symposium, organised by COS Heidelberg , Cluster of Excellence 3D Matter Made to Order and ZmbH will take place on Monday 8th and Tuesday 9th June.

Check out the Zoom schedule below for more information!

Check out this paper, published today on Wiley, describing the first comparative expression profiling in the intestines ...
11/05/2020

Check out this paper, published today on Wiley, describing the first comparative expression profiling in the intestines of patients with Giardia-induced PI-FGID, a collaboration between scientists at Research Network GENIEUR, varying institutes of Universität Heidelberg and Universitetet i Bergen in Norway.

Lead author: Cristina Martínez

Looking for some Sunday reading? Check out this recent pre-print! With Mathis Baalmann as lead author and contributions ...
01/12/2019

Looking for some Sunday reading? Check out this recent pre-print! With Mathis Baalmann as lead author and contributions from CellNetworks member Richard Wombacher, it aims to provide the community with a powerful toolbox for making protein-protein conjugates using bioorthogonal chemistry.

A highly efficient technology for protein functionalization with commonly used bioorthogonal motifs for Diels-Alder cycloaddition with inverse electron demand (DAinv). With the aim of precisely generating branched protein chimeras, we systematically assessed the reactivity, stability and side produc...

The preliminary results of the DFG Review Board Election 2019 have been published! Among this year's members are six Cel...
28/11/2019

The preliminary results of the DFG Review Board Election 2019 have been published! Among this year's members are six CellNetworks scientists! We'd like to congratulate: Britta Brügger, Frank Lyko, Michael Boutros, Rüdiger Hell, Karin Schumacher and Ulrich Schwarz!

"The election of review board members is an important element in the system of scientific self-governance with regard to the distribution of grants through the DFG."

Check out the link below to access the list!

The promotion of equality between women and men in science and academia has been anchored in Section 1 of the DFG's statutes since 2002. Interner Linkmore

Check out this pre-print! With Julia Knopf as lead author and contributions from CellNetworks member Marius Lemberg, it ...
28/11/2019

Check out this pre-print! With Julia Knopf as lead author and contributions from CellNetworks member Marius Lemberg, it describes the group's use of a catalytic-inactive mutant and proteomics to find substrates for the ERAD rhomboid protease.

Comments are highly appreciated (on the webpage)!

The Endoplasmic Reticulum (ER)-resident intramembrane rhomboid protease RHBDL4 generates metastable protein fragments and together with the ER-associated degradation (ERAD) machinery provides a clearance mechanism for aberrant and surplus proteins. However, the endogenous substrate spectrum and with...

The next public event in the development project, "Masterplanverfahren Im Neuenheimer Feld / Neckarbogen," will take pla...
22/11/2019

The next public event in the development project, "Masterplanverfahren Im Neuenheimer Feld / Neckarbogen," will take place on Thursday 28th November 2019 at 6pm.

In the first half of 2019, the four planning offices presented their traffic concepts for the project. After putting their feasibility to the test, an external reviewer will now present its findings, as well as the traffic flows each approach will most likely produce, to the public.

All interested parties are invited to intend. There will be an opportunity to ask questions and submit comments following the presentation. For more information, check out the link below!

Das Masterplanverfahren Im Neuenheimer Feld / Neckarbogen geht weiter: Die vier Planungsbüros hatten in der ersten Jahreshälfte vier Entwürfe samt Verkehrskonzepten für den Campus vorgelegt. Ein externer Gutachter hat diese Verkehrskonzepte nun auf den Prüfstand gestellt. Die Frage war: Halten ...

Check out this recently published paper, with contributions from CellNetworks member Sylvia Erhardt. Lead author: Engin ...
22/11/2019

Check out this recently published paper, with contributions from CellNetworks member Sylvia Erhardt. Lead author: Engin Demirdizen

Abstract. Centromere function requires the presence of the histone H3 variant CENP-A in most eukaryotes. The precise localization and protein amount of CENP-A

19/11/2019

Calling PhD students and postdocs!

Science communication is an increasingly important issue in academia. So why not check out the following opportunity for young scientists!

Dagmar Röhrlich, a renowned science journalist, will be the next Springer Nature Visiting Professor for this topic. During her stays at the Marsilius Kolleg, she will offer several workshops on practical or more theoretical aspects of science communication – some in English and some in German.

A joint initiative of the Veranstaltungsforum of the Holtzbrinck Publishing Group, the Klaus Tschira Foundation (KTS), and Universität Heidelberg, workshop themes this year will include: how to become a good interview partner, how good press conferences work and scientific communication for environmental scientists, among others.

Check out the programme and feel free to register for any of the seminars via email, or send in any questions you might have using the link below!

The visiting professorship for scientific communication, established in the winter term 2018/2019, is a joint initiative of the Veranstaltungsforum of the Holtzbrinck Publishing Group, the Klaus Tschira Foundation (KTS) and Ruperto Carola.

Check out this recently published paper on the interaction of the stem cell inducer WUSCHEL with the differentiation hor...
19/11/2019

Check out this recently published paper on the interaction of the stem cell inducer WUSCHEL with the differentiation hormone auxin, with contributions from CellNetworks members Thomas Greb and Jan Lohmann. Lead author: Yanfei Ma.

Spatial control of auxin signaling maintains a balance between stem-cell self-renewal and differentiation at the plant shoot apex. Here Ma et al. show that rheostatic control of auxin response by the WUSCHEL transcription factor maintains stem cells by conferring resistance to auxin mediated di...

The next round of talks in the series Survival Strategies (Überlebensstrategien), hosted by Universität Heidelberg, is a...
15/11/2019

The next round of talks in the series Survival Strategies (Überlebensstrategien), hosted by Universität Heidelberg, is about to begin! The first event, "Stammzellen," will take place on Thursday 21st November at Karlstorbahnhof at 19:30.

Speakers will include members of CRC 873, such as CellNetworks members Ruiz de Almodóvar (BZH), Jan Lohmann (COS) and Henrik Kaessmann (ZMBH), and Head of the Division of Stem Cells and Cancer at Deutsches Krebsforschungszentrum (DKFZ) and HI-STEM Founding MD Andreas Trumpp.

Survival Strategies is joint project of the Life Science Collaborative Research Centres of the University of Heidelberg and the Rhein-Neckar-Zeitung.

Editors of the newspaper pose questions at each event on the respective research topic, the scientists involved and their methods. This format of moderation is intended to involve the audience and include them in the dialogue. In an informal setting at the Karlstorbahnhof and with musical accompaniment by members of the Collegium Musicum Heidelberg, the Collaborative Research Centres will present their questions and long-term goals.

Check out the link for more details: https://www.uni-heidelberg.de/en/node/5232

Check out this recently published paper detailing how centromeric CENP-A histone incorporation is linked to the spindle ...
15/11/2019

Check out this recently published paper detailing how centromeric CENP-A histone incorporation is linked to the spindle assemly checkpoint, with contributions from CellNetworks member Sylvia Erhardt. Lead author: CN postdoc Anne-Laure Pauleau.

Author summary Segregation of DNA during mitosis is a highly regulated process necessary to ensure the faithful transmission of genetic material to new daughter cells. Centromeric chromatin, which is defined by the presence of the histone H3 variant CENP-A, mediates the interaction of chromosomes wi...

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