Project FOIE GRAS

24/06/2022

🔥 Harsh*tha Shanmugam (ESR 11) from Università degli Studi di Bari Aldo Moro 🇮🇹 concluded her PhD last month 🔥

Entitled "Randomized controlled trial testing the effects of Mediterranean diet, healthy lifestyle habits, and COVID-19 pandemic lockdown on subjects with Non-alcoholic fatty liver disease", her thesis hypothesized that weight loss achieved by a lifestyle intervention program could improve liver steatosis, fibrosis, and the biochemical profile in Non-alcoholic fatty liver disease (NAFLD) patients. Even moderate adherence to Mediterranean diet was sufficient to reverse fatty liver by at least one grade and reduce the fat depositions in the body. Furthermore, the thesis addressed how COVID-19 pandemic lockdown could maginify factors of prior metabolic risks and promote unhealthy lifestyle habits among NAFLD population.

Congratulations Harsh*tha, it was a great pleasure to have you on the FOIE GRAS team!! We wish you the best of luck in the next professional challenges!!

5 more to go... Stay tuned 😊

20/04/2022

🔥 Inês Simões (ESR 1) from Instytut Biologii Doświadczalnej im. M. Nenckiego PAN 🇵🇱 concluded her PhD last week 🔥

During her PhD research work, entitled "Effects of Western diet in the development and progression of Non-alcoholic fatty liver disease", Inês has hypothesized that the onset of a pro-oxidant state act as the trigger to mitochondrial and hepatic-related alterations that may drive by a non-reversible way the disease progression into NASH. Using an in vivo NAFL mice model, she has addressed the distinct role of hypercaloric diets (fat, sucrose or combined fat and sucrose) in an early stage of NAFLD. Furthermore, she has investigated the specific end-points for mitochondrial dysfunction that govern NAFL progression along time. Additionally, she validated a next generation of therapeutics for early stage of NAFLD based on smart antioxidant delivery to mitochondria.

Congratulations Inês, it was a great pleasure to have you on the FOIE GRAS team!! We wish you the best of luck in the next professional challenges!!

6 more to go... Stay tuned 😊

20/01/2022

🔥 Getachew Belew (ESR 4) from CNC UC 🇵🇹 was proclaimed Doctor in Experimental Biology and Biomedicine (specialization of Biotechnology and Health) 🔥

In his study, "Fructose Metabolism and Lipogenesis Fluxes in Mice Models of Diet-induced Non-Alcoholic Fatty Liver Disease", he established mice models using previously recommended approaches to learn fructose metabolism and the contribution of high fructose and/or high fat diets to de novo synthesis of liver triglyceride in diet induced mice models of NAFLD.

Congratulations Getachew, it was a great pleasure to have you on the FOIE GRAS team!! We wish you the best of luck in the next professional challenges!!

7 more to go... Stay tuned 😊

26/11/2021

🔥 Bárbara Patrício (ESR 6) from CNR Consiglio Nazionale delle Ricerche 🇮🇹 was proclaimed Doctor Translational Medicine – Curriculum in Molecular Biomedicine, Experimental and Clinical Physiology and Pathophysiology 🔥

Bárbara's research work aimed to investigate the role of the gut-liver axis in the pathophysiology of NAFLD: specifically, the effects on hepatic lipid metabolism of GLP-1 receptor agonists (GLP-1RA) or bariatric surgery (Roux-en-Y gastric bypass, RYGB) in non-diabetic subjects with morbid obesity and NAFLD and the changes in gut integrity after high-fat high-sugar diet in an animal model of NAFLD.

Congratulations Bárbara, it was a great pleasure to have you on the FOIE GRAS team!! We wish you the best of luck in the next professional challenges!!

8 more to go... Stay tuned 😊

12/10/2021

🔥 Mireia Alemany (ESR 13) from CNC UC 🇵🇹 was proclaimed Doctor in Experimental Biology and Biomedicine (specialty of Biotechnology and Health) 🔥

Mireia's PhD Thesis details the development and evaluation of the persuasive effectiveness of the comic “A Healthy Liver Will Always Deliver!”, an evidence-based graphic narrative strategically built to raise NAFLD awareness and promote healthy lifestyles through nutrition and physical activity habits as preventive and therapeutic strategies against the development of the disease.

Congratulations Mireia, it was a great pleasure to have you on the FOIE GRAS team!! We wish you a lot of success in the next professional challenges!!

9 more to go... Stay tuned 😊

09/09/2021

🔥 Tawhidul Islam (ESR 8 ) from Faculdade de Farmácia da Universidade de Lisboa 🇵🇹 was proclaimed Doctor in Pharmacy, with a specialization in Biochemistry 🔥

During his PhD, entitled "Targeting liver cell metabolism and function in Non-alcoholic Fatty Liver Disease", Tawhidul studied the role of cell death linked to mitochondrial bioenergetic and metabolic function in human and experimental NAFLD and NASH, and evaluated the therapeutic relevance of multiple targeting approaches in the resolution of the disease.

Congratulations Tawhidul, it was a great pleasure to have you on the FOIE GRAS team!! We wish you a lot of success in the next professional challenges!!

10 more to go... Stay tuned 😊

30/07/2021

New FOIE GRAS ITN article from CNC UC 🇵🇹 and Instytut Biologii Doświadczalnej PAN 🇵🇱 groups!

Congratulations to all authors❗️

"Exploratory Data Analysis of Cell and Mitochondrial High-Fat, High-Sugar Toxicity on Human HepG2 Cells." authored by Amorim R, Simões ICM, Veloso C, Carvalho A, Simões RF, Pereira FB, Thiel T, Normann A, Morais C, Jurado AS, Wieckowski MR, Teixeira J, Oliveira PJ has been published at Nutrients (2021), 13(5), 1723.

More info 👉

Non-alcoholic steatohepatitis (NASH), one of the deleterious stages of non-alcoholic fatty liver disease, remains a significant cause of liver-related morbidity and mortality worldwide. In the current work, we used an exploratory data analysis to investigate time-dependent cellular and mitochondrial...

27/07/2021

New FOIE GRAS ITN article from Faculdade de Farmácia da Universidade de Lisboa 🇵🇹 group!

Congratulations to all authors❗️

"The role of RIPK3 in liver mitochondria bioenergetics and function." authored by Islam T, Afonso MB, Rodrigues CMP has been published at European Journal of Clinical Investigation (2021), e13648.

More info 👉

Background Receptor-interacting protein kinase 3 (RIPK3) is a key player of regulated necrosis or necroptosis, an inflammatory form of cell death possibly governing outcomes in chronic liver disease...

26/07/2021

New FOIE GRAS ITN article from Instytut Biologii Doświadczalnej PAN 🇵🇱 and CNC UC 🇵🇹 groups!

Congratulations to all authors❗️

" The Alterations of Mitochondrial Function during NAFLD Progression-An Independent Effect of Mitochondrial ROS Production" authored by Simões ICM, Amorim R, Teixeira J, Karkucinska-Wieckowska A, Carvalho A, Pereira SP, Simões RF, Szymanska S, Dąbrowski M, Janikiewicz J, Dobrzyń A, Oliveira PJ, Potes Y, Wieckowski MR has been published at International Journal of Molecular Science (2021), 22(13).

More info 👉

The progression of non-alcoholic fatty liver (NAFL) into non-alcoholic steatohepatitis implicates multiple mechanisms, chief of which is mitochondrial dysfunction. However, the sequence of events underlying mitochondrial failure are still poorly clarified. In this work, male C57BL/6J mice were fed w...

24/07/2021

Last month, the Project FOIE GRAS had its Final Conference Meeting, where project coordinator, ESRs and Dr. Helena Cortez-Pinto, member of the External Advisor, gave incredible presentations and lectures.

Read the full article ➡️

Last month, on June 16th, the Project FOIE GRAS organised its Final Conference Meeting, where all ESRs had the opportunity to present the final results, outcomes and remarks of their individual res…

23/07/2021

New FOIE GRAS ITN article Università degli Studi di Bari Aldo Moro 🇮🇹 group!

Congratulations to all authors❗️

" Multiplying effects of COVID-19 lockdown on metabolic risk and fatty liver." authored by Harsh*tha Shanmugam , Di Ciaula A, Di Palo DM, Molina Molina E, Garruti G, Faienza MF, vanErpecum K, Portincasa P has been published at European Journal of Clinical Investigation (2021), 51 (7).

More info 👉

Background Social containment measures imposed in Europe during the lockdown to face COVID-19 pandemic can generate long-term potential threats for metabolic health. Methods A cohort of 494 non-CO...