WCM-Q Research

WCM-Q Research The official account of the Research Division at Weill Cornell Medicine-Qatar. We advance biomedical discovery, to improve health in Qatar & beyond.

Research at Weill Cornell Medicine-Qatar

We are proud to share a new publication by Dr. Charbel Abi Khalil and colleagues in the European Journal of Preventive ...
08/09/2026

We are proud to share a new publication by Dr. Charbel Abi Khalil and colleagues in the European Journal of Preventive Cardiology.

🩺 Type 1 and Type 2 diabetes: which one is associated with higher cardiovascular events and mortality?
This invited editorial highlights the critical relationship between diabetes and cardiovascular outcomes, exploring how the risks of cardiovascular events and mortality may differ between individuals with Type 1 and Type 2 diabetes. The article underscores the importance of tailored prevention strategies and cardiovascular risk management across both populations.

Congratulations to Dr. Abi Khalil and co-author Prof. Michel Marre on this important contribution to the field of cardiovascular prevention research.

🔗 Read the article: https://doi.org/10.1093/eurjpc/zwag442

How can the gut microbiota shape human health, and what role will artificial intelligence play in advancing personalized...
07/09/2026

How can the gut microbiota shape human health, and what role will artificial intelligence play in advancing personalized care?
In his recent presentation , Prof. Ludovico Abenavoli highlighted the evolving evidence surrounding f***l microbiota transplantation (FMT), its potential applications across a range of conditions, and the opportunities and challenges presented by AI-driven precision medicine. The discussion emphasized the importance of the gut-liver axis, microbiome-based therapies, and the growing role of AI in supporting clinical decision-making, diagnostics, and research.

As healthcare continues to evolve, integrating innovative technologies with microbiome science may help unlock more personalized and effective approaches to patient care. While promising, further research and clinical validation remain essential.

Congratulations to Dr. Lotfi Chouchane and his team on the inclusion of CDC1011, a novel small-molecule UCP1 activator, ...
06/09/2026

Congratulations to Dr. Lotfi Chouchane and his team on the inclusion of CDC1011, a novel small-molecule UCP1 activator, in the Weill Cornell Medicine technology portfolio. CDC1011 was identified through a proprietary high-throughput screening platform and shows promise as a next-generation approach to obesity and metabolic disease management by promoting healthy adipocyte function and reducing inflammation.

This milestone reflects the growing impact of translational research at WCM-Q and the power of innovation to advance discoveries from the laboratory toward real-world patient benefit.

We also congratulate the team on securing a QRDI Road to BioPharma grant for their innovative AdipoQSwitch Platform, further accelerating efforts to identify selective agonists of healthy human adipocytes.

Special thanks to Dr. Mina Zion and the Cornell CTL/Enterprise Innovation team for their invaluable support in advancing this discovery through intellectual property protection, technology transfer, and commercialization efforts.

🔗 Learn more: https://innovation.weill.cornell.edu/industry-investors-partners/technology-portfolio/ucp1-activators-suppressing-adipocyte-inflammation

A study by our Infectious Disease Epidemiology (IDEG) shows how healthy vaccine bias may lead cohort studies to underes...
03/09/2026

A study by our Infectious Disease Epidemiology (IDEG)
shows how healthy vaccine bias may lead cohort studies to underestimate rare vaccine adverse events, highlighting value of self-controlled case series & triangulating evidence across study designs
📄: https://doi.org/10.1080/14760584.2026.2720953

A comprehensive systematic review and meta-analysis by the Infectious Disease Epidemiology Group examined the epidemiol...
27/08/2026

A comprehensive systematic review and meta-analysis by the Infectious Disease Epidemiology Group examined the epidemiology of Chlamydia trachomatis in Canada & analyzed data spanning more than four decades (1981–2025), providing important insights into infection prevalence, risk patterns, and public health implications. The findings highlight the continued burden of chlamydia and reinforce the need for strengthened screening, prevention strategies, and investment in vaccine development.

Read the full article: https://connectsci.au/sh/article/23/4/SH26066/274590/Epidemiology-of-Chlamydia-trachomatis-in-Canada

Congratulations to Dr. Laith Abu Raddad and his team on this publication.

A new study by our Infectious Disease Epidemiology Group in collaboration with the Biolab Diagnostic Laboratories in Jo...
24/08/2026

A new study by our Infectious Disease Epidemiology Group in collaboration with the Biolab Diagnostic Laboratories in Jordan, provides one of the first comprehensive assessments of the epidemiology of Neisseria gonorrhoeae (gonorrhea) in Jordan using a national laboratory dataset spanning 2014 to 2025.

Analyzing data from 8,779 individuals, the study found a low overall prevalence and incidence of gonorrhea in Jordan. However, higher positivity rates among individuals tested for clinical reasons, coupled with no evidence of a temporal decline in infections, suggest ongoing transmission that warrants continued public health attention.

The findings underscore the importance of strengthening surveillance systems, expanding targeted testing and treatment strategies, and incorporating antimicrobial resistance monitoring to better inform prevention and control efforts.

📖 Read the study: https://ow.ly/Ji5I50ZEonw

A new study demonstrates how a novel fatty acid measurement derived from NMR lipoprotein profiling can uncover genetic ...
23/08/2026

A new study demonstrates how a novel fatty acid measurement derived from NMR lipoprotein profiling can uncover genetic signals linked to fatty acid metabolism.
Analyzing data from over 274,000 participants in the UK Biobank, researchers identified key genetic pathways involved in lipid regulation, providing a valuable new tool for understanding cardiovascular and metabolic health.
Congratulations to the research team, Dr. Abdelaziz Belkadi, Dr. Gaurav Tharja, Nisha Stephan, Dr. Anna Halama and Dr. Karsten Suhre on this important publication in the Journal of Proteome Research.
📚 https://doi.org/10.1021/acs.jproteome.6c00107

New publication in iScienceResearchers from the Ca²⁺ Signaling Group have identified a previously unknown endoplasmic r...
20/08/2026

New publication in iScience
Researchers from the Ca²⁺ Signaling Group have identified a previously unknown endoplasmic reticulum structure, the cER-basket, that plays a critical role in regulating intracellular calcium signaling. Using a combination of 3D ultrastructural reconstruction, mathematical modeling, and experimental validation, the team demonstrates how this specialized cellular architecture supports calcium tunneling and shapes signaling dynamics. The findings provide new insights into how cellular structure influences signaling specificity and function, advancing our understanding of fundamental mechanisms that govern cell behavior.
Congratulations to Dr. Raphael Courjaret, Dr. Khaled Machaca, and colleagues on this important contribution to cell biology and calcium signaling research.
🔗 https://doi.org/10.1016/j.isci.2026.116955

📢 New Editorial Published in Expert Review of VaccinesAggregate analyses can sometimes obscure important temporal and do...
19/08/2026

📢 New Editorial Published in Expert Review of Vaccines

Aggregate analyses can sometimes obscure important temporal and dose-specific safety signals.
In this new editorial, the Infectious Disease Epidemiology Group (IDEG) demonstrates how stratified self-controlled case series (SCCS) analyses can provide deeper insight into vaccine safety by examining shorter risk windows, stroke subtypes, and vaccine dose number.
🔬 A reanalysis of stroke following COVID-19 mRNA vaccination in Qatar found that the overall signal was concentrated in the first week after vaccination and was largely driven by the first vaccine dose.
Importantly, these findings do not establish causality. Rather, they illustrate how refined SCCS analyses can uncover nuanced, hypothesis-generating patterns that may be missed by conventional aggregate approaches.
📊 The work highlights the value of incorporating clinically informed stratification into vaccine safety SCCS studies while interpreting newly identified signals cautiously and validating them through further analyses.
Congratulations to and colleagues in the IDEG group on this important methodological contribution to vaccine safety research.

🔗 https://www.tandfonline.com/doi/full/10.1080/14760584.2026.2653749

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