04/01/2022
A Snowball's Chance: Resurrecting the Yeti Genome from Glacially Preserved Genomic Specimens
Join us on Friday, 4/1 at 1:30 pm in MCMR 205 to hear from Dr. Eric Hayden, Associate Professor, Biology, Boise State University
Abstract: Yetis have been described in folklore for centuries as ape-like, bipedal creatures that leave behind huge footprints in the Himalayan mountains of Nepal, Bhutan, and Tibet. Recently, receding glaciers have allowed researchers to collect samples of fur, bone, teeth, skin, and f***s from a wild area of Nepal known as the Barun Valley. The samples contained well-preserved intact DNA, but mitochondrial DNA sequencing could not unequivocally assign a species to the sample because it had markers of both hominids and bears. Here I report the sequencing and reconstruction of the first draft genome of the Yeti. A combination of short reads (Illumina), chromatin conformation capture (Hi-C) and long-reads (PacBio) were used to reconstruct the genome. The reconstructed genome contained 23 diploid chromosomes, like humans, but was an estimated ~2.6 Gigabases in size, making it intermediate between the size of polar bears and humans. We have obtained adult polar bear stem cell samples from Point Defiance Zoo (Tacoma, WA), and are using CRISPR/Cas9 to edit the genomes of the cells to include the single-nucleotide polymorphisms, chromosomal rearrangements and gene deletions needed to produce viable Yeti chromosomal DNA. In the near future, this DNA can be transplanted into polar bear egg cells and used to artificially inseminate captive polar bears which will give birth to live Yetis, potentially bringing back to life creatures that currently only exist in our imaginations.
Seminar is open to the public and will be held in MCMR 205 or via zoom.