HSPH Superfund Research Program

HSPH Superfund Research Program Metals and Metals Mixtures: Cognitive Aging, Remediation, and Exposure Sources (MEMCARE) Superfund Research Center at the Harvard T.H.

Chan School of Public Health funded by the National Institute of Environmental Health Sciences (NIEHS) The Superfund Research Program is a national university-based research program funded through the National Institute of Environmental Health Sciences. Kickstarted in 1987 through the Superfund Amendments and Reauthorization Act (SARA), this program called upon universities to resolve the many com

plex health and environmental issues originating at hazardous waste sites. Health concerns of aging—especially cognitive decline and memory loss in older age—have huge public health implications as the United States and world populations are shifting in distribution toward older ages. While a variety of toxicants contribute to cognitive aging, we are focused on heavy metals (Pb, As, Mn, Cd, Cr, and Se) and metal mixtures because, despite years of regulation, clean-up, and remediation efforts, metal contamination in many Superfund sites persists and continues to threaten public health. The mission of our Superfund center is to understand and mitigate the effects of exposure, particularly early life exposure, to metals and metal mixtures on late life cognitive health.

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MEMCARE: Metals and Metals Mixtures: Cognitive Aging, Remediation, and Exposure Sources

The NIEHS Superfund Research Program is a national university-based research program funded through the National Institute of Environmental Health Sciences. Kickstarted in 1987 through the Superfund Amendments and Reauthorization Act (SARA), this program called upon universities to resolve the many complex health and environmental issues originating at hazardous waste sites. The overall goal of our Center is to understand and mitigate the effects of exposures to metals and metal mixtures found at Superfund sites, particularly during critical time periods such as early life, on late-life cognitive health. We have four research projects that address epidemiology, mechanistic laboratory studies, biogeochemical studies on environmental exposures, and engineering to explore remediation strategies for metals in drinking water.