Harvard Center for Biological Imaging

Harvard Center for Biological Imaging The Harvard Center for Biological Imaging is one of the most innovative biological imaging centers i

Under the direction of Harvard faculty member Jeff Lichtman, HCBI Director of Imaging Doug Richardson, and in partnership with Carl Zeiss Microscopy; the HCBI is now recognized as a true “Evergreen” microscopy facility. In order to ensure investigators always have access to the latest and best technologies, the six most advanced imaging systems at the HCBI are replaced every 2-3 years, ensuring th

at the facility remains relevant and is never in possession of outdated equipment. Currently, the HCBI contains 16 microscopes and high-end processing stations including:

* LSM 710 ELYRA PS.1 - a multi-function super-resolution & confocal microscope system (LSM 710 confocal/TIRF/SIM/PALM/dSTORM)

* LSM 780 - an upright confocal configured for 2-Photon imaging

* LSM 880 Airyscan inverted confocal with environmental control and extreme sensitivity & super-resolution through its unique detector

* LSM 700 inverted confocal for routine and advanced imaging

* CellObserver.Z1 - a fully environmentally controlled inverted widefield microscope for long-term imaging & screening

* AxioZoomV16 fluorescence zoom microscope

* AxioScan Z.1 - a high throughput slide scanner

* Lightsheet Z.1 - a selective plane illumination microscope for fast and extremely gentle live cell imaging

The facility also features wet lab space, eukaryotic and prokaryotic incubation, and access to nearby animal care facilities for a wide range of species. Further, Sven Terclavers, an embedded Zeiss specialist, is also present in the facility to assist with experimental design, advanced imaging configurations, training, and troubleshooting. All microscopes are covered under platinum service agreements to ensure rapid repair and minimum down times.

Life of an imaging facility director.
09/06/2017

Life of an imaging facility director.

03/27/2017

Keep an eye out on this page! We'll soon be back with news about our latest systems, upgrades, Lunch & Learn presentations and much more!

12/27/2016

We wish all our facility users and followers on Facebook a Merry Christmas and a wonderful New Year. May 2017 bring prosperity, good health and many discoveries (preferably at HCBI 😉)!

09/08/2016

Sebastian Gliem will help us celebrate ZEISS Microscopy Carl Zeiss’ 200th birthday. Hear about the history of microscopy and the ZEISS Group company. Also enter your name in a raffle to win a $500 voucher for the HCBI. Next Wednesday, September 14, at noon. More info: http://hcbi.fas.harvard.edu/event/lunch-and-learn-history-microscopy

Sebastian Gliem will help us celebrate Carl Zeiss’ 200th birthday. Hear about the history of microscopy and the ZEISS company. Also, enter your name in a raffle to win a $500 voucher for the HCBI.

08/10/2016

Lunch&Learn, tomorrow at 12PM in Room 1080 of the Biological Labs: Sebastian Gliem talks about optimizing your experiment settings to get the best results in fluorescence imaging. More info: http://ow.ly/uM643035AGR. As always, pizza on the house!

Which microscope should you choose? How can you optimize all of those settings in ZEN to improve your image quality? Sebastian Gliem will tell you how!

07/04/2016

Next Wednesday, 07/06, Doug Richardson will be talking about Fluorescence Lifetime Imaging at the Lunch&Learn session. Don't miss it, as FLIM has been added as a new application to our microscope systems! More info: http://ow.ly/PbfX301Urgv

Doug Richardson will be speaking on fluorescence lifetime, a unique characteristic of each fluorophore, and how it can be exploited with new equipment at the HCBI.

Great Nature Communications article shows a deeper insight in replication and maturation of malaria parasites. Our ZEISS...
05/19/2016

Great Nature Communications article shows a deeper insight in replication and maturation of malaria parasites. Our ZEISS Microscopy LSM710 ELYRA PS.1 was used to visualize the localization of PfMOP (P. falciparum merozoite organizing protein) in three dimensions.

Congrats to the Stevens lab! Great ZEISS Microscopy ELYRA images reveal insights to Alzheimer's disease: Science - http:...
04/10/2016

Congrats to the Stevens lab! Great ZEISS Microscopy ELYRA images reveal insights to Alzheimer's disease: Science - http://bit.ly/1RRzKCr

ReportNEURODEVELOPMENT Complement and microglia mediate early synapse loss in Alzheimer mouse models Soyon Hong1, Victoria F. Beja-Glasser1,*, Bianca M. Nfonoyim1,*, Arnaud Frouin1, Shaomin Li2, Saranya Ramakrishnan1, Katherine M. Merry1, Qiaoqiao Shi2, Arnon Rosenthal3,4,5, Ben A. Barres6, Cynthia…

02/24/2016

Great Tissue Clearing poster from ZEISS Microscopy referencing Cell Press article from D. Richardson & J. Lichtmann. Download here: http://ow.ly/YHey5

01/02/2016

We would like to wish everyone a wonderful 2016, and to all researchers here, many great publications! Our resolution for this year, is to improve on supporting your imaging & analysis needs, whether you are an academic or private company researcher. Let us know how we could help you even better!

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02138

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