05/28/2026
🔬 New Research Highlight from Our Department! 🔬
We’re proud to share a new publication from the lab of Professor Karen Beningo, led by graduate student Jacob DeTone:
DeTone J, Kozole S, Stewart M, Hao B, Beningo KA
Basigin (CD147) and Calpain 4 (CapnS1) are partners in the generation of traction force but not in mechanosensing
Journal of Biological Chemistry
https://www.jbc.org/article/S0021-9258(26)02042-9/fulltext
How do cells move? This study explores the teamwork behind cell movement—an essential process in wound healing, immune response, and even cancer spread.
They identified two proteins, Basigin and Calpain 4, that work together to help cells generate the physical forces needed to move. Interestingly, while Calpain 4 plays a role in both force and sensing, Basigin is uniquely involved only in generating movement itself, not in how cells 'sense' their surroundings
By separating these two processes, force generation and sensing, this work helps refine our understanding of how cells navigate their environment, with potential implications for biomedical research.