09/03/2026
Parasitic nematodes cause human diseases and damage more than $100 billion in crops annually, and they are spreading beech leaf disease, which is threatening New Hampshire forests.
Chemical-based approaches to controlling them are highly toxic, but researchers at the University of New Hampshire are now investigating a metabolic pathway that could provide a way to manage them in the Granite State and around the world with far lower environmental consequences.
NHAES scientists Rick Cote and Kranti Galande worked with C. elegans, a small nematode widely used in research.
They focused on inhibiting the activity of a family of proteins known as phosphodiesterases (PDEs). PDEs are vital for regulating the levels and activity of signaling molecules that nematodes need for proper function.
They were surprised to find that inhibiting or eliminating a single PDE had little effect, but the nematodes were killed or impaired when multiple PDEs were targeted.
"A ‘cocktail’ of PDE inhibitors targeting multiple PDEs may provide a very effective way to manage plant-parasitic nematodes and improve agricultural productivity,” says Cote.
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UNH College of Life Sciences and Agriculture UNH Research