02/01/2026
"Looking back over my life, I am struck by the good fortune I have had to be a scientist. Very few in this world have the opportunity to do every day what they love to do, as I have," said Linda Buck.
Buck was fascinated by one seemingly simple question: how does our sense of smell work?
First, she had to figure out how the nose detects odours. She embarked on the search for odour receptors in 1988, and worked intensely for three years. In results published in 1991, Buck and her research partner Richard Axel pinpointed 1,000 types of olfactory receptors in mice, located in the back of the nose, on a spot called the olfactory epithelium. Humans have 350 of these olfactory receptors.
She continued to work on her research for another ten years and was able to map the organisation of the olfactory system from the nose to the brain.
In this system, each olfactory receptor detects more than one odorant and each odorant can be detected by more than one receptor. Working together, the receptors create a “combinatorial code” forming an “odorant pattern” to identify specific odours. This code underlies our ability to recognise more than 10,000 different odours.
Buck was awarded the Nobel Prize in Physiology or Medicine in 2004.
Learn more: https://bit.ly/3718u0Y