06/01/2026
Why do mitochondrial DNA mutations accumulate across generations, and what role do specific enzymes and pharmaceuticals play in that damage? Those are the questions driving Sophia Cochran's research, and at the 2026 Conference of Florida Graduate Schools, she had just three minutes to explain it to a room full of strangers.
In work conducted in collaboration with the NIH, Sophia found that Triumeq, a widely used antiviral, may increase mitochondrial DNA mutations that can be passed to future generations. She is also studying how defects in a key replicative enzyme, Helicase Twinkle, contribute to mitochondrial disorders. With 1 in 200 people carrying a mitochondrial DNA mutation and no cure currently available for mitochondrial disease, identifying what causes that damage matters enormously.
Sophia competed in the statewide Three Minute Thesis (3MT) competition, distilling that complexity into a single slide and three minutes of spoken word. "I am thankful that I was selected to represent UNF," she said. "It reminded me that my hard work and dedication was noticed."
Her advice to other graduate students: "Say yes to every opportunity. See presentations not as a performance, but as a way to share the importance of your work."
Sophia is considering PhD and MD-PhD programs, with a long-term focus on the factors that contribute to mitochondrial disease development, treatment, and prevention.