Soper Research Group

Soper Research Group Development of Micro- and Nanofabricated Tools for Biological Discovery and Medical Diagnostics

The major focus of our group is to generate new tools for discovery and medical diagnostics through the analysis of biological macromolecules including DNAs, RNAs and proteins. These tools cover a diverse range of activities, such as the generation of new reagents, novel assays and methodologies, and hardware innovations across various length scales (millimeter to nanometer). What is particularly

compelling with our major research goal is that these tools are being integrated into operating systems that can be used for a variety of applications, such as the diagnosis and prognosis of many forms of cancers, stroke and infectious diseases. In order to build systems specifically designed for macro-molecular analyses, our research spans many sub-areas, such as polymer-based micro- and nanomachining, fluorescent probe development, construction of ultrasensitive detection apparati and nano-biology (performing molecular biological reactions in ultra-small volumes). In addition, we are currently working with collaborators in several areas, such as mechanical engineering, molecular biology, surface science, materials, organic chemistry and mass spectrometry. Provided below is a short description of a few of our many projects. To facilitate these multi-disciplinary efforts, our group is part of the Center for BioModular Multi-Scale Systems, which is a multi-institutional research center with access to state-of-the-art equipment and expertise in many disciplines in the sciences and engineering as well.

We are on our way to tour Fenway park!
06/28/2025

We are on our way to tour Fenway park!

06/17/2025

The Center of BioModular Multiscale Systems for Precision Medicine (CBM2, https://cbmm.ku.edu) invites you to its Annual Workshop “How to Make It/How to Use It” at the University of Kansas, Lawrence Campus from August 6 – August 8, 2025. The workshop co-sponsored with Center for Molecular Analysis of Disease Pathways (CMADP, https://cmadp.cobre.ku.edu) and will focus on “Plastic Microfluidics for Biomedical Applications” and will include lectures and hands-on experiments.

Registration costs will be covered by CBM² and NIH. Travel and accommodation are the responsibility of the participant.

Please email Jo Sabus ([email protected]) to register. Enter subject line: "CBMM Workshop 2025 registration"

06/12/2025
01/14/2025
11/22/2024

It was great to see everyone at this week's SelectBio Lab-on-a-Chip and Microfluidics World Congress 2024!

Thanks to everyone who attended Dr. Soper's keynote presentation: "Label-Free Detection and Identification of Single Molecules for Applications in biology and Medicine"

The National Organization for the Professional Advancement of Black Chemists (NOBCChE) has officially recognized the KU ...
10/18/2024

The National Organization for the Professional Advancement of Black Chemists (NOBCChE) has officially recognized the KU chapter of its organization. Proud of the members of the Soper lab who were instrumental in its formation!

Read more about the conference on our website:

The National Organization for the Professional Advancement of Black Chemists formally recognized the KU chapter at its annual conference in September.

10/08/2024

Assessment of minimal residual disease (MRD) is the most powerful predictor of outcome in B-type acute lymphoblastic leukemia (B-ALL). MRD, defined as the presence of leukemic cells in the blood or bone marrow, is used for the evaluation of therapy efficacy. We report on a microfluidic-based MRD (MF...

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1567 Irving Hill Rd
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