09/29/2020
Congratulations to Souhrid Mukherjee for being GSA’s student of the Month for September! Check out his interview below:
1. Whose lab are you in?
I am co-mentored by Prof. Tony Capra, PhD and Prof. Jens Meiler, PhD (Vanderbilt Chemistry dept and Leipzig University, Leipzig, Germany)
http://www.capralab.org
http://www.meilerlab.org
2.What year of your PhD are you in?
I am starting my 5th year (I came to Vanderbilt in 2016)
3.What is your thesis project about?
My research focus is digenic diseases, which are phenotypes that are caused / exacerbated by variants in two genes. It has been shown that gene pairs known to cause digenic disease share several biochemical attributes, such as common pathways and co-expression. I was curious whether these shared attributes could be leveraged to develop a high-throughput method to predict whether a gene pair could cause digenic disease if harboring rare variants simultaneously.
I have developed a machine learning algorithm to identify digenic pairs in humans. The machine learning classifier used these shared biochemical attributes and was trained on known digenic pairs and several negative controls. The preprint for our manuscript can be found here: https://www.biorxiv.org/content/10.1101/2020.05.31.125716v1
I am a member of the Personalized Structural Biology (PSB) team, a part of the Center for Structural Biology (CSB), here at Vanderbilt University. We have been working on combing computational structural biology, systems biology, genomics and human evolution to facilitate better interpretation of the effect of missense variants on protein structure and function.
Our research is in collaboration with the Undiagnosed Diseases Network (UDN), which is a team of clinicians and researchers striving to diagnose patients with very severe, rare and complex phenotypes. We strive to help identify rare variants, in one of more genes, that may affect protein function and could explain the complex and unresolved patient phenotypes.
4.What advice would you offer to other graduate students to help them be successful?
My advice would be (cliched as it is ) : Do what makes you happy. Choose a lab or PI where you feel the most comfortable. Choose your research topic based on what you’re interested in and not what you think will have the highest impact factor publication. Know you, do you, be you, because YOU are awesome.
5.What is a fun fact about you?
My hobbies are learning to cook exciting new foods, playing video games (offline) and reading/performing (non-musical) theater.
Fun fact: I played the role of a lysosome in an allegorical political satirical play, written by my friends and me, during my MS