10/27/2026
In the largest genetic study of personality to date, Penn Medicine researchers have uncovered 1,260 genetic variants associated with the “Big Five” personality traits.
“There isn’t a single gene for being outgoing or conscientious,” says psychiatrist Henry R. Kranzler. “What we see instead are thousands of genetic differences that individually contribute a small amount, but collectively shape personality alongside the many influences of a person’s environment.”
In the largest genetic study of personality to date, researchers from the Perelman School of Medicine uncovered 1,260 associated variants and found that thousands of small genetic effects help form the Big Five traits in addition to environmental influe...