06/02/2026
UW researcher Kevin Lin aims to better understand one of the biggest mysteries in current Alzheimer’s research: the phenomenon of resilience, why roughly 30 percent of people who never show signs of cognitive decline are later found to have high levels of Alzheimer’s pathology in their brains.
Lin, along with his collaborators in UW Medicine, recently received a $75,000 award from the UW Alzheimer’s Disease Research Center (ADRC) for a project examining this mystery through microglial resilience and data integration.
The team’s innovation lies in building an AI-based pipeline to link two completely different data types: the physical 3D shapes (morphology) of immune cells captured via high-resolution microscopy and the genetic blueprints (transcriptomics) of those same cells.
“By linking structure to function, we can finally begin to see the full picture of what makes a brain resilient,” said Lin.
Read more about the work at: https://www.biostat.washington.edu/news/stories/solving-alzheimers-mystery
University of Washington School of Public Health