Team Moghaddam

Team Moghaddam Team Moghaddam is a basics science research lab in the Department of Pulmonary Medicine at UT MD Anderson Cancer Center located in the Texas Medical Center

The research in Moghaddam Laboratory focuses on airway inflammation and its role in airway epithelial tumorigenesis. Cigarette smoking is the principal cause of lung cancer. However, several studies have found that smokers with chronic obstructive pulmonary disease (COPD), an inflammatory disease of the lung, have an increased risk of lung cancer compared to smokers with comparable cigarette expos

ure but without COPD. Importantly, among smokers with COPD, even following smoke cessation, inflammation persists as does the increased risk of lung cancer. These facts suggest a strong link between COPD-related airway inflammation and lung cancer which is being studied and mechanistically dissected in Moghaddam Laboratory. In brief, we study the role of epithelial innate immune signaling pathways and inflammatory cells recruited by these signals to mechanistically dissect the promoting role of airway inflammation in lung carcinogenesis. Students and fellows working in Team Moghaddam have the opportunity to study lung biology, airway inflammation, molecular aspects of lung cancer, and tumor microenvironment while applying different techniques in related genetically engineered mice. Our research projects, by having the potential to detect and target important microenvironments and pro-carcinogenic pathways in the lungs, would have a major impact on preventing the leading cause of cancer death by providing the basis for rationally directed therapy in patients at high risk for lung cancer development, and patients with early stage tumors.

09/03/2020
09/03/2020
09/02/2020
Enjoy our latest publication
09/02/2020

Enjoy our latest publication

Through lost- and gain-of-function studies, our data suggest that estrogen exerts a context-specific anti-tumor effect through inhibiting NF-κB-driven tumor-pro

We set a record with publishing 4 papers during past 4 months ending it with this novel study (see below). I am really p...
11/08/2018

We set a record with publishing 4 papers during past 4 months ending it with this novel study (see below). I am really proud of my research team. None of these wouldn't be happening without their hard work and love for science. Way to go folks. You are amazing.

Proinflammatory and immunomodulatory events that drive development of K-ras mutant lung adenocarcinoma (LUAD) are poorly understood. Here they develop a lung epithelial specific K-ras mutant/Stat3 conditional knockout mouse model and show a sex-specific role for epithelial Stat3 signaling in K-ras-m...

Team Moghaddam travels to D.C. to attend the annual ACCR meeting
05/26/2017

Team Moghaddam travels to D.C. to attend the annual ACCR meeting

07/22/2016

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