Center for Cell Reprogramming

Center for Cell Reprogramming The CCR promotes research on stem-like cells, with an emphasis on CRC's and adult stem cells and their relevant biological and medical applications.

The Center for Cell Reprogramming has a vision to promote research on stem-like cells, with an emphasis on conditionally reprogrammed cells and adult stem cells and their relevant biological and medical applications. We strive to be a nidus for faculty recruitment and for attracting external funding from the NIH, DOD, pharmaceutical companies and foundations. We are currently working on infusing t

he university, via seminars, with the most current scientific information generated by world class stem cell scientists. Our goals is to be a key in performing groundbreaking investigations into the genetic and molecular basis of disease by means of investigating the genetic heterogeneity of cancers, identifying markers of indolent versus aggressive cancers, investigating the mechanisms involved in migration and metastasis, testing, on a patient-by-patient basis, tumor cell sensitivity to radiation- and chemo- therapy, and advancing techniques in regenerative medicine and stem cell reconstitution. We have a goal to integrate complementary stem cell and stem cell-like research approaches with basic, translational and clinical themes.

The Frontiers in Oncology journal is currently running a Special Issue "Current Status and Recent Advances in Preclinica...
05/08/2023

The Frontiers in Oncology journal is currently running a Special Issue "Current Status and Recent Advances in Preclinical Models for Rare Cancers" (ISSN 2234-943X, IF 5.738).

This Special Issue aims to identify novel preclinical models for rare cancers used in various areas of cancer research, in terms of their importance for translational research.

They would like to collect manuscripts describing the advances in preclinical models’ development that can provide valuable information for researchers and clinicians strategizing new therapeutic/diagnostic approaches. A broad range of research (Original Research, Methods, Review/mini-Review articles) is welcomed. You can learn more about the collection here:

Cancer, a very diverse group of diseases, is considered a major health burden globally, being one of the leading causes of death in many countries. Among known cancers, there is a subset of malignancies with extremely infrequent incidence and a variety of genotypes and phenotypes – they are charac...

Researchers from Georgetown University Medical Center including CCR's own Ewa Krawczyk, have identified a biological pat...
05/10/2022

Researchers from Georgetown University Medical Center including CCR's own Ewa Krawczyk, have identified a biological pathway that is activated when tissue is starved of oxygen due to rapid growth of a tumor, thereby allowing cancer cells to make genetic changes so they can metastasize to the bone and thrive even when exposed to chemotherapy.

In studies using mice grafted with human Ewing sarcoma tissue, researchers have identified a biological pathway that is activated when tissue is starved of oxygen due to rapid growth of a tumor, thereby allowing cancer cells to make genetic changes so they can metastasize to the bone and thrive even...

We are excited to conclude our 2021-22 season of CCR Seminar Series with a special seminar by Dr. Cyrus Ghajar at Fred H...
03/29/2022

We are excited to conclude our 2021-22 season of CCR Seminar Series with a special seminar by Dr. Cyrus Ghajar at Fred Hutchinson Cancer Research Center in WA. He will present on "Understanding and Overcoming Immune Evasive Properties of Dormant Disseminated Tumor Cells" Hope to see you there!

03/02/2022
CCR is proud to cosponsor a special seminar with the Bhussry Seminar Series on February 22, 2022 at 12pm. Dr. Joseph Bo...
02/22/2022

CCR is proud to cosponsor a special seminar with the Bhussry Seminar Series on February 22, 2022 at 12pm. Dr. Joseph Bonventre from Harvard Medical School will talk on "Human Kidney Organoids and Organoid Derived Cells to Interrogate Kidney Biology”.

If you are a student, faculty or staff member of the Georgetown University community, we invite you to join us on Februa...
02/03/2022

If you are a student, faculty or staff member of the Georgetown University community, we invite you to join us on February 9, 2022 to hear Dr. Michael Shen. He will be speaking on "Investigating Lineage Plasticity Using Patient-derived Organoid Models of Bladder Cancer”. The seminar starts at 11am and contact Rachel Choi for a zoom link. See you there!

We're excited to kickoff our first 2021-2022 CCR Seminar Series with Dr. James Kirkland! Join the webinar to hear his ta...
12/01/2021

We're excited to kickoff our first 2021-2022 CCR Seminar Series with Dr. James Kirkland! Join the webinar to hear his talk on "Aging, Cellular Senescence, and Senolytics: The Path to Translation" on December 8th at 11am.

A new article by Dr. Seema Agarwal and Jerry Xiao, MD-PhD candidate was just published on Biomedicines. Read about "Circ...
09/03/2021

A new article by Dr. Seema Agarwal and Jerry Xiao, MD-PhD candidate was just published on Biomedicines. Read about "Circulating Tumor Cells: Technologies and Their Clinical Potential in Cancer Metastasis"

Circulating tumor cells (CTCs) are single cells or clusters of cells within the circulatory system of a cancer patient. While most CTCs will perish, a small proportion will proceed to colonize the metastatic niche. The clinical importance of CTCs was reaffirmed by the 2008 FDA approval of CellSearch...

Dr. Anton Wellstein's review on studying of Cell-free DNA (cfDNA) tags is published on Frontiers in Genetics. Read how ...
08/23/2021

Dr. Anton Wellstein's review on studying of Cell-free DNA (cfDNA) tags is published on Frontiers in Genetics. Read how it may lead to a better understanding of how to assess and possibly modulate treatment approaches for cancer and other diseases.

WASHINGTON (July 27, 2021) — Cell-free DNA (cfDNA) shed into the blood was discovered in the late 1940s, but with rapid advances in genomics and computational analytics in just the past few years, researchers at Georgetown Lombardi Comprehensive Cancer Center now believe that studying tags, or mod...

A recent publication featuring CCR's Dr. Ewa Krawczyk is now out on Frontiers in Cell and Developmental Biology article....
08/03/2021

A recent publication featuring CCR's Dr. Ewa Krawczyk is now out on Frontiers in Cell and Developmental Biology article. Read about how “Neuropeptide Y/Y5 Receptor Pathway Stimulates Neuroblastoma Cell Motility Through RhoA Activation”.

Neuropeptide Y (NPY) has been implicated in the regulation of cellular motility under various physiological and pathological conditions, including cancer dissemination. Yet, the exact signaling pathways leading to these effects remain unknown. In a pediatric malignancy, neuroblastoma (NB), high NPY....

Our MD-PhD candidate, Jerry Xiao, is one of two winners of the Proteintech 2021 AACR Research Grant. Historically, Prote...
05/03/2021

Our MD-PhD candidate, Jerry Xiao, is one of two winners of the Proteintech 2021 AACR Research Grant. Historically, Proteintech has supported young scientists for their career development through travel grants to the AACR annual meeting. As this year’s conference is virtual, they offered two $1,000 grants to be used for cancer research instead. Congratulations, Jerry, we are so proud of you!

Proteintech Group, Inc.: Antibodies for every human protein

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